By Marc A. Williams

Pt. 1. floor amendment suggestions -- pt. 2. Analytical options and purposes

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Extra resources for Allergens and respiratory pollutants: The role of innate immunity

Sample text

Physiological barriers, for example as provided by the epithelial cells lining the lung, the skin, mucous membranes and complement in the blood benefit from the collaboration of the cell-mediated phagocytic and endocytic uptake mechanisms that collectively provide a first line of defense that is always present and rapid in its response. Soluble factors and other physiological barriers that precede the recruitment of the adaptive immune response provide a second line of defense, which is not always constitutively present.

15 Tauber AI. (1992). The birth of immunology. III. The fate of the phagocytosis theory.

Thus there is cooperation between the strictly antigen-specific adaptive and antigen non-specific innate immune responses. Cells that constitute the innate immune system, such as professional antigen-presenting mononuclear phagocytes, are said to synapse with and promote activation of T cells that are crucial components of the adaptive immune response. However, the innate immune system plays a dominant role in the elimination of most exogenous infectious or non-infectious agents that challenge the host.

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